What to Avoid When Taking Low Dose Naltrexone: A 2025 Wellness Guide

The Rise of Low Dose Naltrexone in Holistic Health

Low Dose Naltrexone (LDN) isn’t just a niche remedy anymore. From autoimmune warriors to individuals with chronic fatigue and fibromyalgia, this therapy has found its way into mainstream wellness conversations.

But just because something is “low dose” doesn’t mean it’s risk-free.

Understanding what to avoid when taking low dose Naltrexone is essential—especially if you’re hoping for optimal results without setbacks.

Let’s explore what medical experts and patients alike are learning about how to get the best out of LDN.

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1. Avoid Opioids at All Costs

LDN is a known opioid receptor antagonist. This means that it blocks the very same receptors opioids activate. If you’re still on opioids—whether prescription-based or recreational—starting LDN can lead to sudden withdrawal symptoms like:

• Sweating

• Nausea and vomiting

• Anxiety

• Tremors

Since starting LDN while still on opioids can trigger sudden withdrawal, patients who cannot safely stop on their own may require a medically supervised opioid detox before beginning treatment.

What to do instead:

You must discontinue opioids at least 7–14 days before starting LDN. Always do so under medical supervision.

Common opioids to stop before LDN include:

• Codeine

• Hydrocodone

• Oxycodone

• Morphine

• Tramadol

• Fentanyl

📘 External reference: Drugs.com on Naltrexone Interactions

2. Be Mindful of Over-the-Counter Medications

Certain OTC drugs contain hidden opioid-like ingredients or interact poorly with LDN.

OTC products to be cautious with:

• Cough syrups (with dextromethorphan)

• Antidiarrheal medications like loperamide

• NSAIDs like ibuprofen or aspirin (if used excessively)

Some of these drugs may weaken LDN’s effect or stress your liver unnecessarily.

3. Limit or Avoid Alcohol

While LDN is sometimes prescribed for alcohol use disorder in higher doses, it’s not wise to combine excessive alcohol with LDN therapy. LDN is metabolized in the liver—and so is alcohol.

Overburdening your liver can result in:

• Elevated liver enzymes

• Decreased drug efficacy

• Long-term organ stress

Rule of thumb: Keep it moderate or opt for alcohol-free alternatives during your LDN journey.

4. Monitor Liver Function

Because LDN is processed by your liver, those with existing liver issues (e.g., hepatitis, fatty liver) need to tread carefully.

Before starting LDN, your doctor may request:

• Liver function tests (LFTs)

• Regular checkups during treatment

📗 Supporting data via Palm Harbor Pharmacy

5. Discuss Mental Health Medications

If you’re taking medications for depression, anxiety, or bipolar disorder, some interactions may occur.

Medications to mention to your doctor include:

• SSRIs (like Prozac or Zoloft)

• Antipsychotics (like Abilify or Seroquel)

• Benzodiazepines (like Xanax or Ativan)

While LDN is often well tolerated, always keep your prescribing doctor informed to avoid mood destabilization or reduced drug effectiveness.

🔗 Interaction checker at Drugs.com

Alsor read: Audrey Gruss: A Philanthropist on a Mission to find the Cure for Depression

6. Pregnancy and Breastfeeding

Pregnant or planning to conceive? The safety of LDN in pregnancy hasn’t been thoroughly studied. While some women with autoimmune conditions choose to continue it, always consult with an OBGYN first.

The same goes for breastfeeding mothers—data is limited, and safety is not fully established.

Also read; Navigating Pregnancy After 35: Understanding Risks and Taking Precautions

7. Be Cautious with Supplements and Herbs

Supplements can either enhance or inhibit LDN, depending on their mechanisms.

Herbs to be careful with:

• Kava and Valerian root (may sedate or suppress nervous system)

• Milk thistle (can alter liver enzyme levels)

• CBD and THC (mixed reports on compatibility)

Ask your integrative doctor to review your entire supplement stack before beginning LDN.

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Conclusion: A Balanced Approach Brings the Best Results

Taking low dose naltrexone can be life-changing—but only when you respect the boundaries of what not to combine it with. From avoiding opioids to reducing alcohol and watching supplement intake, a few simple precautions can make all the difference.

🧠 LDN isn’t a silver bullet, but it’s a powerful ally—if you use it wisely.

Also read: Things to Avoid with Degenerative Disc Disease